منابع مشابه
Microvesicles as cell-cell messengers in cardiovascular diseases.
Cell-cell communication has proven to be even more complex than previously thought since the discovery that extracellular vesicles serve as containers of biological information on various pathophysiological settings. Extracellular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies, originating from different subcellular compartments. The cellular machinery ...
متن کاملMembrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.
Thrombus lysis is the consequence of a restricted number of reactions localized on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may lead to thrombosis with severe or fatal clinical consequences. Despite this clinical need, and real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors an...
متن کاملLevels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality
BACKGROUND Microvesicles (MV) have been implicated in the development of thrombotic disease, such as acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF). Trauma patients are at increased risk of late thrombotic events, particularly those who receive a major transfusion. The aims of this study were: (a) to determine whether there were increased numbers of pro-coagulant MV...
متن کاملDiacylglycerols and phosphatidates: which molecular species are intracellular messengers?
In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase p...
متن کاملActive endocannabinoids are secreted on the surface of microglial microvesicles
MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...
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ژورنال
عنوان ژورنال: Seminars in Immunopathology
سال: 2011
ISSN: 1863-2297,1863-2300
DOI: 10.1007/s00281-011-0276-6